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Monday, May 18, 2020 | History

4 edition of Nicotine C-oxidation by human liver microsomes found in the catalog.

Nicotine C-oxidation by human liver microsomes

Nicotine C-oxidation by human liver microsomes

a major role for CYP2A6.

  • 71 Want to read
  • 15 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1996.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL16973815M
ISBN 10061219213X
OCLC/WorldCa46562417

  Nicotine, the major addicting agent in tobacco and tobacco smoke, undergoes a complex metabolic pathway, with ∼22% of nicotine urinary metabolites in the form of phase II N -glucuronidated compounds. Recent studies have shown that UGT2B10 is a major enzyme involved in the N -glucuronidation of several tobacco-specific nitrosamines. In the present study, microsomes Cited by: Messina ES, Tyndale RF, Sellers EM () A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J Pharmacol Exp Ther – PubMed Google Scholar Meunier V, Bourrie M, Julian B, Marti E, Guillou F, Berger Y, Fabre G () Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human Cited by:

  Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. , 50, −), it was demonstrated that human liver microsomes Cited by:   Cytochrome P 2A6 (CYP2A6) is a human enzyme best known for metabolizing tobacco‐related compounds, such as nicotine, cotinine (COT), and nitrosamine procarcinogens. Cited by:

  Nicotine is primarily metabolized to cotinine in humans. In this study, human cytochrome P (CYP) isoform involved in cotinine formation was identified. The formation of cotinine in 16 Cited by:   A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. Messina ES, Tyndale RF, Sellers EM. J Pharmacol Exp Ther, (3), 01 Sep Cited by: Cited by:


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Nicotine C-oxidation by human liver microsomes Download PDF EPUB FB2

Author information: (1)Osaka Prefectural Institute of Public Health, Japan. Nicotine C-oxidation by recombinant human cytochrome P (P or CYP) enzymesand by human liver microsomes was investigated using a convenienthigh-performance liquid chromatographic by:   Nicotine C-oxidation by recombinant human cytochrome P (P or CYP) enzymes and by human liver microsomes was investigated using a convenient high-performance liquid chromatographic by: A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

Messina ES(1), Tyndale RF, Sellers EM. Author information: (1)The Addiction Research Foundation and the Department of Pharmacology, University of Toronto, Ontario, Canada. Nicotine is primarily metabolized to cotinine by cytochromes P Cited by: Messina ES, Tyndale RF, Sellers EM () A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

J Pharmacol Exp Ther (3)– PubMed Google Scholar Meunier V, Bourrie M, Julian B, Marti E, Guillou F, Berger Y, Fabre G () Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human Cited by: N-Oxygenation of Primary Amines and Hydroxylamines and Retroreduction of Hydroxylamines by Adult Human Liver Microsomes and Adult Human Flavin-Containing Monooxygenase 3.

Chemical Cited by:   In the presence of human brain microsomes, along with nicotine‐ N ‐oxidation, we also detect nicotine oxidation to nicotine iminium ion.

However, unlike N ‐oxidation, this activity is NADPH independent, does not follow Michaelis‐Menten kinetics, and is not inhibited by NADP or carbon by: 2. Request PDF | Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes | Excess nicotinamide, a form of vitamin B(3), is metabolized through two enzymatic systems and eventually.

In the presence of human brain microsomes, along with nicotine‐N‐oxidation, we also detect nicotine oxidation to nicotine iminium ion. However, unlike N‐oxidation, this activity is NADPH.

Nicotine & Tobacco ResearchDOI: /ntr/ntr Mitsuo Miyazawa, Shinsuke Marumoto, Toshiyuki Takahashi, Hiroshi Nakahashi, Risa Haigou, Kyousuke Nakanishi. Metabolism of (+)- and (-)-Menthols by CYP2A6 in Human Liver by: In vitro studies using human liver microsomes revealed that the menthol enantiomers, (+)-menthol and (À)-menthol, are oxidised in the liver principally by the CYP2A6 enzyme to (+)-trans-p.

However, nicotine and cotinine are both glucuronidated at the nitrogen atom of the pyridine ring. We report here that human liver microsomes catalyze both the N-glucuronidation and the O-glucuronidation of trans-3‘ Cited by: by nicotine, cotinine, and an aqueous cigarette tar extract (ACTE) in human 2E1-expressing microsomes.

At all substrate concentrations (0– mM) nicotine was a significantly more potent inhibitor of CYP 2E1 activity compared to cotinine. Estimated Ki values for nicotine.

Nicotine or cotinine was incubated with human liver microsomes and UDP-glucuronic acid in a μl incubation mixture. The nicotine N -glucuronide (Nic-glu) and cotinine N -glucuronide (Cot-glu) formed were analyzed by ion-pair chromatography with a C Cited by: 8.

The formation of both cis- and trans-nicotine-1'-N-oxide in rat liver microsomes was inhibited by the addition of 1-(1-naphthyl)thiourea or by heat-treatment of microsomes.

2-Diethylaminoethyl. Liver microsomal nicotine C-oxidation also was increased ( to fold). CYP2B selective inactivators demonstrated that approximately 70% of nicotine C-oxidation was mediated by CYP2B1/2 in both EtOH-induced and uninduced hepatic by: Download Citation | N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases | Nicotine is considered the major addictive.

Books A - Z; Journals A - Z; Videos; Librarians; Browse Volumes & Issues. Archives of Toxicology. All Volumes & Issues.

Vol Issue 2, April ISSN: (Print) (Online) In this issue (9 articles) TOXICOKINETICS AND METABOLISM. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. E.S. Messina, R.F. Tyndale, E.M. SellersA major role for CYP 2A6 in nicotine C-oxidation by human liver microsomes J Pharmacol Exp Ther, (), pp.

Google ScholarCited by:   A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. In vitro inhibition of cytochrome P enzymes in human liver microsomes by a potent CYP2A6 The Cited by:   Incubation of human liver microsomes with nicotine gave keto acid by using aminoketone as an intermediate; keto acid was not formed from cotinine.

In 10 human liver samples, rates of Cited by:. Journals & Books; Help Download full advances in the understanding of the interindividual variability in nicotine metabolism have been made.

() 41) H. Yamazaki, K. Inoue, M. Hashimoto, T. Shimada, Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes Cited by:   Nicotine is primarily metabolized to cotinine by cytochromes P (CYPs). The degree of variation in the metabolism of nicotine to cotinine and the relative roles of the polymorphic enzymes Cited by: 1.

Introduction. Alcoholic liver disease (ALD) is a serial of liver disorders caused by heavy alcohol drinking. The spectrum of ALD ranges from hepatic steatosis (fatty liver) to steatohepatitis, fibrosis and cirrhosis [].Many of the toxic effects of ethanol have been linked to its metabolism in the liver Cited by: 1.